The efficacy of aromatase inhibitors in men

Our physician will review these results with you and create a customized treatment plan if hormone replacement is warranted. It is important to remember that the best TRT clinic knows the importance of estrogen to male physiology. The Alpha Hormones TRT clinic does not aim to inhibit estrogen production – only to maintain the right balance between testosterone and estrogen.

After taking it daily for 10 days, a suppression of only 38 % was found 24 hours after the last administered dose.
Age, weight and certain genetic predispositions will cause more risk in some men than others for excessive estrogen production when receiving Testosterone Replacement Therapy.
Resveratrol inhibits the aromatase at both the enzyme and mRNA levels, similar to Gingko Biloba (R), however, resveratrol itself is highly estrogenic so I would not recommend using it.
Using PEDs comes with risks, but with the right precautions and supplements, you can mitigate these and maintain your health.

Estrogen blockers typically act as aromatase inhibitors (AIs), meaning they bind to the aromatase enzyme and deactivate it. Aromatase inhibitors reduce the conversion of testosterone into estrogen (estradiol) and androstenedione into estrone, the latter being a minor estrogenic hormone in men. Testosterone replacement therapy (TRT) is growing in popularity for treating low testosterone levels. The conundrum some men face is that estrogen levels tend to increase as testosterone levels do. As part of the steroidogenesis pathway, testosterone is metabolized into either dihydrotestosterone (DHT) by the 5-alpha reductase enzyme or estradiol by the aromatase enzyme. Aromatase inhibitors can successfully be used in order to suppress estrogenic side-effects on a high-dose TRT protocol and/or a protocol with an infrequent injection frequency.

When aromatase inhibitors reduce estrogen levels, several side effects can arise. Unfortunately, there is no information on whether aromatase expression is modified in the human brain after traumatic injury or stroke. Nevertheless, a recent study has reported an increase in serum aromatase levels 24 h after stroke in postmenopausal women.105 The functional significance of this finding is, however, unclear. Although aromatase concentration in serum has been shown to represent a good biomarker for some types of cancer,106 it is unknown whether it may be affected by modifications in aromatase expression in the brain. Too much estrogen can cause health issues for males, but unusually low testosterone levels can also have a negative effect. For example, males are at higher risk for developing osteoporosis if their estrogen levels are too low.

HORMONE HEALTH

This research was supported by the Intramural Research program at NIH, National Institute of Aging. Authors are most grateful to Dr. Sokratis Makrogiannis for his help with the software for quantitation of CT thigh. In addition, authors are most grateful to all the participants who took part in this study. All scans were performed at the mid-thigh level, halfway between the femoral head and patella, with a 500 × 500 mm field-of-view, 512 × 512 image matrix, and 10 mm image thickness. The mid-thigh scans provided subcutaneous fat measurements (cm2) and were analyzed using Tibest version 1.4, a semi-automatic image quantification platform developed in-house (Makrogiannis et al., 2012).

Efficacy of anastrozole in the treatment of hypogonadal, subfertile men with body mass index ≥25 kg/m2

(C) Pyramidal neurons in the Pyr of the hippocampal Ammon’s horn CA1 region showing aromatase immunoreactivity in the perikaryon and in the basal and apical dendrites. (D) Pyramidal neurons in the Pyr of the hippocampal Ammon’s horn CA3 region showing aromatase immunoreactivity in the perikaryon and dendrites. (E) Hippocampal dentate gyrus showing aromatase immunoreactivity in granule cell neurons in the Gr and a few interneurons in the Hil. All panels are Steroids from immunoperoxidase-stained sections using hydrogen peroxide as substrate and 3,3′-diaminobenzidine tetrahydrochloride as chromogen. In (B), the reaction was intensified by adding a small amount of nickel chloride. Gr, granular layer; Hil, hilus; Mol, molecular layer; Or, Stratum oriens; PC, Purkinje cell layer; Pyr, pyramidal layer; Rad, Stratum radiatum; Wm, white matter.

Transparent Labs Vitality is a 3-in-1 hormone optimizing supplement that features clinical doses of natural ingredients discussed throughout this article, such as DIM, zinc, and organic ashwagandha root extract. It not only helps increase testosterone production but also controls the amount that is converted to estrogen. Read on to learn about estrogen blockers for men and how aromatase inhibitors work. When you come off of a steroid cycle, your testosterone levels drop off but estrogen levels stay elevated.